I would like to pass on my experience with the Leqvio injection. In August of 2023 I received my first injection. I had familial high cholesterol all my adult life. My cardiologist suggested the Leqvio because I had muscle and joint pain with statins. I reluctantly agreed to try. I do have osteoarthritis in my knees and I have occasional lower back pain because of spinal issues but nothing serious. After 2 other injections, I did notice several problems, such as, minor UTI's, a resurgence of my acid reflux which I've had under control for 15 years. Also joint and muscle pain which I attributed to arthritis. Then after my injection in October of 2024 my sciatica flared; I was unable to sleep more than 2 hours at a time. So I was always tired, plus now I was in constant pain or having leg cramps. I even stopped driving for fear of getting a leg cramp. I was also unable to sit or stand for more than 10 or 15 minutes at a time, I was also using a cane to help me walk. The family doctor sent me for several tests, especially since I already had edema in my legs. All my bloodwork and test results were good; no signs of any problems. I had an endoscopy which simply said I had inflammation, but why? I also went to a rheumatologist who did many blood tests, especially for autoimmune diseases. Again everything came out good. I then had pain first in my right wrist, then in my left. The orthopedist diagnosed me with tenosynovitis of dequervains. I received a cortisone injection in each wrist; I am still having pain in my wrists. My next doctor was a spinal surgeon who sent me for an MRI which showed issues which I already knew about. He suggested PT which I did twice weekly for 3 months. This helped, but I still had the intense pain. My next step was going to be a neurologist. At that time I ran out of my B12 supplement and decided to research different brands. I came across an article on the Mayo Clinic website where they were talking about Thorne vitamins and supplements. So I decided to give them a try. After day one of my first 1000mg B12 I noticed a difference; by day three my intense pain had not only diminished, but disappeared. I still have some pain, but it's very manageable without the Tylenol that I needed daily before. I am continuing my exercises from PT in the hopes that I can be totally pain free eventually. It hasn't been a good two years of this journey from the Leqvio injection. Yes my cholesterol dropped to low levels, but the other issues far surpassed those results. This journey has been mine; you might not have some or any of these problems. My problem has also been that the cardiologist didn't really believe me; that's why I went to so many different doctors looking for an answer and help.