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Is hormone therapy necessary with radiation?
Prostate Cancer | Last Active: Jul 19 8:36pm | Replies (104)Comment receiving replies
@jeffmarc It was the SPPORT trial I was thinking of. The key SPPORT result was freedom from progression (FFP) at 5 years.
The three arms were approximately:
Treatment Arm 5-Year Freedom From Progression
Prostate bed RT alone ~71%
Prostate bed RT + 4-6 months ADT ~81%
Prostate bed RT + pelvic node RT + 4-6 months ADT ~87%
So the absolute differences were roughly:
RT + ADT vs RT alone: +10 percentage points
RT + pelvic RT + ADT vs RT alone: +16 percentage points
RT + pelvic RT + ADT vs RT + ADT: +6 percentage points
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@dhasper
This does sound impressive. I think it would be hard to find a doctor that would do the prostate bed without doing the lymph nodes these days.
The study up above, that I referred to, Was almost definitely doing lymph nodes. They did find 10 year survival was almost identical, ADT or not.
Then you come up with the aggressiveness of the case and that’s another major factor That may have been not been discussed in the SPPORT trial. High PSA’s before radiation or other aggressive issues can make ADT the desirable result. There are so many choices.