@hrbirk Welcome to Mayo Clinic Connect and this support group.

I'm going to do a thorough search through the peer-reviewed literature in professional journals. I'd like to see if there is evidence for this late onset syndrome that you've mentioned.

Here is an excellent discussion of myofascial syndrome and the mechanisms. I could not find anything in the peer-reviewed literature (published in professional journals) that studied Reclast with this syndrome.

Gromakovskis V (2025) Exploring fascia in myofascial pain syndrome: an integrative model of mechanisms. Front. Pain Res. 6:1712242. doi: 10.3389/fpain.2025.1712242

-- https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2025.1712242/full

I had 12 months of Evenity in 2024 followed by a Reclast infusion upon finishing the Evenity. I then had another Reclast infusion in 2025. My bone density scores have impressively improved. I too have experienced more stiffness but also hip joint pain. I have a left total hip replacement that was performed at Mayo in 2019. In the past few months I am having enough pain that I made an appointment with my orthopedic surgeon to "rule out" or "rule in" whether this is a hardware problem.

I have no regrets on the total hip replacement as I would not be able to walk or be this active had I not had it. I also have no regrets on the medication (Evenity and Reclast) ordered by my endocrinologist. I just want to know what's going on!! I lift weights a minimum of two times a week with a personal trainer. I'm wondering if I did something to my hips while lifting.

Is there anything you do to help relieve the pain? Stretching? Yoga?