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PMR. Endocrine or Rheumatology Issue?

Polymyalgia Rheumatica (PMR) | Last Active: Jun 11 9:21am | Replies (16)
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Profile picture for bettebaldwin @bettebaldwin

Thanks for this prompt response @johnbishop A good bit of bedtime reading for me here! Papers which certainly look in my interest area. I'll have a look @dadcue too.

Glad to hear you're in remission. I'm relatively recently diagnosed and keen to really understand this endocrine underpinning.

Thanks again. Bette

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Replies to "Thanks for this prompt response @johnbishop A good bit of bedtime reading for me here! Papers..."
Mike | @dadcue | Jun 6 11:12am

@bettebaldwin

The site where excessive amounts of inflammation occurs makes PMR a rheumatology issue. Then the PMR rheumatic issue becomes more of an endocrine issue after we take prednisone for PMR.

The PMR endocrine issue more or less "perpetuates" the PMR rheumatology issue because, when we take prednisone, we "shut down" the endocrine system that regulates inflammation which is the HPA axis. The endocrine issue is why we have to taper off Prednisone slowly. The side effects from prednisone are almost entirely an endocrine issue.
https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis
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The interplay of rheumatology and endocrinology is what makes PMR and the treatment for PMR so complicated.

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