That is a really good, thought-provoking question. I have felt weepy as I get down to the lower doses of Prednisone. In a strange way it seems freeing to fell the weepiness, as I seem to be giving expression to the things that may have contributed to overload, which may have set up the PMR condition. I seem to be putting thoughts in slots, and the weepiness seems not only a good thing, but appropriate. In other words, I probably should have been crying before, but couldn’t. Great question, Thanks.

Maybe it's not the prednisone tapering but the PMR itself causing you to feel this way. The tapering is just a reminder of what you have gone through, and still are.

I am struggling with depression, I’m now down to 2 1/2 mg of prednisone. I’m trying to be proactive: going outside, meeting with friends, eating good food and setting small goals. It helps until the evening when I crash.

I have been experiencing this but I tapered to zero and not my pain is returning. Mornings are the worst. I don't know if I am weepy from chronic pain or being disappointed that the PMR is returning or was never gone. I don't want to go back on prednisone but the pain is getting hard to tolerate. Most days I improve by mid afternoon.

Hello @staylorrn2000,

I combined your discussion with an existing discussion titled:

"PMR and Depression"
- https://connect.mayoclinic.org/discussion/pmr-and-depression-1/

Here you can meet members talking about tapering off of prednisone and experiencing symptoms including depression among others.