@dks2500 I have tolerated BCG well. No complications. Nurses said that some patients who have had chemo prior to BCG have discomfort. Vesta biomarkers indicated only a 60 % chance of success. Just before my third scraping I asked the surgeon about the biomarkers. He said not enough research has been completed to justify the biomarkers predictions. That’s why they still do the BCG even if you have the failure biomarkers. They consider it the gold standard. For men it’s about 90 seconds of discomfort. Nothing to fear. Embrace it and see if it works for you.