@dd74

Since you are a nurse and one of those seronegative types ... have you ever tried a biologic? I'm both of those two things too,

I took prednisone for 30 years for a variety of problems. My first 15-20 years were not because of PMR . I took prednisone intermittently in high doses but I tapered off quickly. I was doing "reasonably well" until I started taking prednisone every day for PMR over the last 12 years. When I took prednisone every day for 12 years to treat PMR ... my overall health and well-being declined precipitously.

I tapered off prednisone about 6 years ago after a biologic called Actemra (tocilizumab) was started. It was still very difficult to taper off prednisone but now I have enjoyed a "prednisone free remission" for the last 6 years. My quality of life has vastly improved since I tapered off prednisone.

Mentally, a therapist I saw once said I had elements of medical PTSD. I told her that was from being a nurse!