Approximately 20 years ago depression was overwhelming. My doctor wanted me at the highest dose of 225mg (3 tabs of 75 mg) daily because she said that’s when it’s most efficient. I did not realize that there were any side effects until I forgot to take it for two days…all I could do was cry! It was very confusing. But now, at age 72, I am ready to try to wean off…my family doctor says that’s it’s very difficult (understatement!) but that I should try to take 2 tablets daily, which I have tried to do. With the brain zaps I decided to take 2 tabs then an occasional day with 3 tabs…more later!