Hi njc, I am 76 and have been diagnosed With SFN at least 10 years ago by two biopsies. I don't have the burning in my feet any more but the numbness continues and has gone up almost to my knees. I also have CRPS in both feet so it's hard for me to distinguish what is causing the pain. My feet are contracting much more lately. The numbness in my hands has me dropping things without realizing I have let go. It gives me exercise as I have to bend down and pick it up. That's a good thing. LOL. I am not aware of any brain involvement. I also have a spinal cord stimulator implanted due to disc problems which is great for my pain. I have sciatica problems as well.. But the best that I have is a marvelous pain management doc. who is brilliant and is always happy despite dealing with people's pain all day..