← Return to Research: Effects of Hypertonic Saline on Bronchiectasis

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Profile picture for bernadene24 @bernadene24

Thank you, Kathy, for posting this.
If I am reading correctly, the inhaled saline, both .9% and 6% gave similar positive results long term. Good news. Makes me wonder if the nebbing itself is more important than the strength of the saline. I have been nebbing 7% saline for over a year now religiously 2x a day. Over this time my coughing has increased both while doing the nebbing and throughout the day, and I generally feel crummy afterward. My scans and Pulmonary Function Tests have remained pretty stable.
Yesterday I had dental surgery which requires me to suspend the nebbing and aerobika for a few days. I feel so much better and have almost no coughing! I have two more days of abstinence to go, so it will be interesting to see how I fare, coughwise. I'm not saying no to nebbing. I firmly believe that it is important for me to clear out the mucus and the bugs swimming around in it. (I have MAC and Pseudomonas along with mild BE). I am wondering, however, if cutting back to a weaker solution (3%), would irritate me less. My concern about doing this is that maybe the MAC and PA would have a more comfortable living arrangement. Does anyone know if there has been a study looking at whether a stronger solution of saline has a greater negative effect on MAC and PA? Thanks for any input you might have.

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Replies to "Thank you, Kathy, for posting this. If I am reading correctly, the inhaled saline, both .9%..."

@bernadene24 You're welcome, Bernadene. I have the exact same question and concerns. I wouldn't make the change based on 1 study, particularly considering the sample size of those with NTMs. I would definitely discuss with both your ID and Pulmonary doctors, particularly since you have a chronic cough-which isn't good either. My NJH doctor last May told me she wanted me to stay on the 7% Hypertonic saline after I briefly went on the 3%. Since then, I have had very low counts: 32, 0,0,0,22,8, and waiting on my 7th sample. About 6 months ago, I developed a bad cough asked her if I could take a break from the 7% and use the 3% and she said it was fine. I'm now back on the 7% since I determined the cough was more asthma related but thinking of talking to her again about maybe go to 3% for a longer period and see if it effects my counts. In your case, I really think you should discuss with your doctors. It's a shame there aren't more studies on this. Also, I have found about 4 or 5 saline studies (I couldn't find the other one I wanted to post) and haven't seen any saline nebulizing studies comparing MAC and Pseudomonas. No doubt in my mind, there would have been more studies (and larger groups for specific treatments) if saline was a $5000/month plus drug.