@rlpostrp

That is not true. Cancer in very small amounts can not be seen on scans, not even PSMA.

Cancer cells can escape prostate gland well before surgery via blood, lymphatic system, neural bundles etc. That way micro metastasis are established and can start growing on their own in proximity or in distant places.

There are many , many patients here with negative margins and intermediate, gleason 7 cancer that ended up with BCR. That is absolutely not an anomaly.

On the other side, there are patients with positive margins, EPE and gleason 9 who did not have BCR in many years post op.

With PC there are just NO rules and no certainty.