@kfhoz The other side of that coin would be Radius investing in some case studies/clinical trials to show that it's safe and still effective....although less effective than the 80 micrograms per their clinical trials, but still the dosing versatilitt exists as an option rather than patients completely having to abandon the drug. We all know money drives businesses. Radius is still getting the same money, whether we throw away an empty cartridge after 30 days or one that still half full. Some providers simply need a general statement that says at the discretion of the prescribing physician, the option exists to adjust the dosage to mitigate side effects...with a note thatbindicates the effectiveness may be less than the full dose determined to be the best via clinical trials. Anything official to even let them providers know that the pen is adjustable and titrtsting is an option. If they could do some case studies to determine if daily lower doses & titrating recs is more effective than full doses every other day would be icing on the cake. Who knows how many patients Radius has lost, due to full-dose side effects and physicians not realizing dosing adjustments are even an option. Sure seems like a little investment money on their part would increase their potential patient base. I had a lengthy discussion with a specialty pharmacist who has been on calls with Radius in the past. He agreed that it would be very beneficial for all, if they would release some of their clinical trial data or conduct some case studies, and produce a cartridge that is potentially half the size of the current one for those people needing reduced doses vs. tossing half cartridges in the garbage. 10 years from now, I trust more physicians will be comfortable adjusting the doses, like they do now with many other medications, but because Tymlos's is relatively new, that comfort level does not exist with some at this point. For those of us making decisions now on our osteoporosis journey, our 24 month window is closing quickly. Future data releases/discoveries will have no bearing for us, but may certainly help others.