@brainhealth I've been on gabapentin since Sept 2025. I started at 300mg per day (100mg in morning, afternoon, night) and am now on 700mg (300mg at night due to severe muscle lockups but it hasn't helped). I have paraneoplastic syndrome along with SCLC (waiting for an accurate diagnosis of which syndrome) causing extreme leg stiffness which has put me on a walker since Aug 2025. I have not noticed any improvments from this drug but as my symptoms have worsened my neurologist keeps upping the dose. Paradoxically, I am working to improve balance and leg strength with a PT but the side effects from this drug can cause fatigue, dizziness, and balance issues so finding the right dosage is difficult or impossible. I am also on baclofen which seems to cause stiffness more than alleviate it. I hate baclofen more than I hate gabapentin but have been told my my local neurologist there aren't many other options. So I went to Mayo where they are in the process of hopefully providing an accurate diagnosis and more treatment options than these two drugs. Bottom line, I cannot tell whether gabapentin is actually helping me or not, but I do have extreme fatigue in the afternoons from it and now am afraid to go off of it in case that causes my symptoms to get worse. Vicious cycle.