I'm a 57yr woman who had my DNA testing over 20years ago. In my Health Predisposition it shows I have two copies of the E4 variant APOE gene. My grandmother had Parkinson's /dementia start in I think her early 70's. My mother (her daughter) passed from Covid at 77yrs. My father passed at 87 w/ AML. So I'm not sure if either of them would shown signs of MCI/Alzheimers.
I started menopause at 49yrs and some things over the last 3 yrs (forgetting why I walked in room to get something, family member saying "I already told you that", brain fog some days worse than others. I have read up on things that come along with menopause and been told by Dr's it's part of menopause (I haven't been on any HRT until this January 2026-compounding hormones). Was told this would clear my "brain fog" but haven't seen any difference.

In 2025 I came across APOLLO HEALTH/brainscan by neurocode...stating you could get a blood test showing results for Phosphorylated Tau 217, Neurofilament Light (NfL), Glial Fibrillary Acidic Protein (GFAP). So I ordered the lab request (out of pocket-wasn't cheap)
I was/am taken back by my results:
p-Tau 217= 0.85 Highest
NfL= 18.12 Normal
GFAP= 75 High
I made copies of my results showed my primary (who wasn't concerned) I asked for a referral to a Neurologist (My previous Neurologist retired-seen for abdominal migraines). New Neurologist dismissed how my testing was done and didn't feel anything was wrong even showing him my DNA along with the blood test. I pushed asking if additional testing could be done, so he ordered a MRI, EEG.
MRI results "no significant white matter signal changes"-appears normal, no major signs of damage inflammation or disease like stroke, multiple scleorsis, leukodystrophies. MRI didn't show hyperintensities or dark areas-which usually signifies demyelination, inflammation or small vessel disease. impression "no acute intracranial abnormality and so on. He didn't explain results just said normal MRI. My EEG "is OK"
I again told the Neurologist my concerns, he again felt he didn't know this Dr or Apollo testing nonsense. I pushed for further cognitive testing. I got an appt in a year for a memory loss center that will further evaluate, test etc.
I have read up on a lot of MCI and Alzheimer's and blood test that can be false positive. I don't know if I am over reacting or if I should do further testing like the PET scan? The Apollo Health Dr. Bredesen Protocol was out of pocket expense and was high monthly expenses. Just lost as to what path I need to walk next.
thank you 🙂