← Return to Polymyalgia Rheumatica (PMR): Meet others & Share Your Story

Discussion
Comment receiving replies
Profile picture for jodirothe @jodirothe

Hi - I was diagnosed with PMR in November of '25 and have been on prednisone since then. Prednisone helped a lot initially but when tapering down to ten I flared and it hasn't stopped - even when adding mexotrexate weekly. In fact the mexotrexate has made me dizzy and done nothing to help with the pain. I've had three doses of the mexotrexate so far. Anyone else on mexotrexate - or have success stories???? I could use encouragement as I just had to cancel a trip I was looking forward to due to fatigue and pain. Thank you - Jodi

Jump to this post


Replies to "Hi - I was diagnosed with PMR in November of '25 and have been on prednisone..."

Welcome @jodirothe, Sorry to hear that you are struggling with the tapering down with prednisone and had to cancel a trip. It's not an easy task and a little different for everyone. You are not alone and there are quite a few members who have experience with methotrexate. Here's a search of Connect listing the different discussions and comments from members with links to their posts - https://connect.mayoclinic.org/search/.

I struggled with tapering off of prednisone during my first occurrence of PMR and it took me 3-1/2 years before I was able to stop the prednisone. The second time around six years later it was a little easier and I was able to get off of prednisone in 1 and half years. You might find this discussion started by @dadcue helpful, especially the reference links in the discussion description:
-- How to Slowly and Safely Taper Off Prednisone but ... no set rules.
https://connect.mayoclinic.org/discussion/how-to-slowly-and-safely-taper-off-prednisone-but-no-set-rules/
Are you able to discuss the tapering and symptoms with your rheumatologist or doctor to see if they may have some suggestions?

Sorry to hear about your PMR . The most important thing to do is the taper and to get your own body starting to produce what it is missing and needs. That means exercise at least 60 minutes a day , Like a stationary bike and taper in smaller doses only after you have stabilized where you are. Sometimes 1 mg is too much. So stabilizing where you feel good, Exercise and decrease with smaller amounts. For me it was at 5-6 that I hit the the point where I needed to taper in smaller amount. It took me about two years to taper from when I first noticed it to totally getting of it(Prednisone) and only prednisone.