@lightlifts I was always able to do the full dose. Because my gains in spine were so good, I stopped Tymlos after 15 months. I had previously had trouble with Fosamax (developed GERD), so my dr suggested Reclast or Prolia. Because of my age, my dr preferred Reclast because with good experience, I will do a Reclast infusion for 3 years, then have a drug holiday. It is all about keeping bones as strong as possible to buy time as we age. A friend of mine fractured a vertebrae, then found out she had osteoporosis and her spine degradation did not give doctors enough to work with for surgery, so she had to go on Forteo first. BTW, I believe with Prolia, very hard to stop treatment as that can increase fracture risk. I just had my Reclast infusion and about 24 hours after infusion I became very tired, like the flu, but no fever or aches. That lasted 2 days. Then I had mild pain in my hips and back. That was intermittent for 5 days. Then good, so far. I followed protocol to drink 64-80 ounces of water days before infusion and days after, and take Tylenol and antihistamine (Benadryl just before infusion). My infusion was 30 minutes of saline, 30 minutes of Reclast, 30 minutes of saline. I cannot consider HRT as I have a blood clotting disorder and it raises my risk of stroke. Good luck! A good Dr. is IMO an important advisor. I was also reluctant to risk taking drugs, but ending up with fractures that compromised my active life scared me more,