I was on Tymlos for 15 months. Spine BMD improved from -3.5 to -1.9, so successful treatment. I did not want to risk further degradation of my bones at my age (65). I had always taken supplements and exercised but BMD had continued to decline, thus I decided to try Tymlos. I was fortunate to have very very mild side effects…injected right before bedtime, had mild heart palpitations or a headache for maybe 15 minutes. The injection itself is easy and not painful.