@bmfoster No to myasthenia gravis. My neurologist started to put me on midodrine then changed his mind to go off label with mestinon as it has a blood pressure raising effect during the day when bp bottoms out while losartan lowers it at night. Timing is everything. I am glad he thought of it. Even in heat and standing I never get below 80/50 although I am grossly weak when it is that low.