@margottaylor A doctor prescribed either 3 or 4 (I think ir was 4) ibuprofen 3 times a day for me to use indefinitely for some pain, I think it was bursitis. After a while I chose to stop it despite it giving me relief - it just did not seem right to me. I wondered when I developed liver problems, cirrhosis, if that could have contributed but I was assured that it would not have. So, a high dose taken regularly can cause liver problems? I know that now being post-transplant I cannot take it but I think that is because of some conflict with the immunosuppressants,
JK