@rc4mc
I was on the big 3 MWF and didn't feel well with the relatively high doses of medication, Rifampin in particular. My UCSF doctor took me off Rifampin and switched me to daily M-F medications at much lower doses. It has worked well for me and now I am adding Arikayce. If you have a hard time with the higher doses, I suggest you ask your doctor about switching to daily doses. Also, I'd like any feedback on Arikayce that anyone can offer. I have read studies that say it is more effective as one of the Big 3, but I am worried about tinnitus, which I already have from Azithrymicin, and the time it takes to nebulize in addition to daily saline nebulizing. I may switch to Chlorfazamine (spelling?) and am interested in learning more about this group's personal experiences and pros and cons of both. Good luck to you.