@lj22 I am HER2 stage2, have had chemo, lumpectomy, radiation. I tried anastrazole, but oncologist switched me to letrozole. I am 7 months in and have pretty major side effects, but am afraid to stop. I may be switched again, but I wanted to tell you I am also being given Zometa every three months for two years. I am one year in and it is not causing me much grief. The only side effect is a slight fluey feeling the day after. I am afraid of osteoporosis so for me, it’s a good thing. Good luck!