If you have autoimmune disease it is what it is. Finding a cause is not the issue. It is not going to go away. You treat the symptoms and hope for the best. Some things work for some and not for others. It is a crapshoot pretty much. I refuse to take biologics because they cause liver damage. I am not looking to trade one nasty issue for a nastier one. I treat mine all natural. It helps in my case but might not work in yours. Water therapy has been fabulous for my PN. You must exercise because with neuropathy it really is the case of you don't use it you lose it. It feels good also. I take apple cider vinegar, ginger root, Alpha Lipoic Acid, and Turmeric (2-3 grams per day) all in capsule form. I also take CBD with higher THC content. I wish you the very best and God Bless.