@susanf8 I do have a GI, she is a new one, she is the 3rd one in 4 years. I met with her on a Zoom and met with her in an office visit which didn't really last very long. She put me on vancomycin, 125 mg capsules, 1 capsule twice/day. I was having leakage during the night for a couple years. Since I have been on the vancomycin, I am having leakage, cramping and seem unable to empty my jpouch. I am having cramps in my gut and in my rectal area day & night. I'm not sure if it is antibiotic related, but it sure seems like it. I did not have symptoms like this when I was on a cipro/flagyl rotation but then still had some leakage during the night but was able to control mostly during the daytime. I am seriously considering an ileostomy, I am 65, and am feeling housebound as I can't plan anything currently, I just want to get back some type of control over my body. I am about 4 hours one way from Mayo, so I have not been in touch with my GI yet about these current issues. I believe that I do have a current order to see a colorectal surgeon, but have not met with them at all yet. I had my jpouch done at Mayo in 1996.