When I took 2 out of the 3 AI's, my blood pressure continued to rise. I'd had moderately high BP before, but manageable with meds. The AI's kept raising it to the point that it became ultra-high. I now have labile hypertension, a real pain to deal with daily now. I have since found research that anyone with cardiovascular problems should not be put on AI's. the Fulvestrant shots I took next caused vein insufficiency in my legs. I am not a candidate for hormone blockers. Here's one such report : https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.e12549