I’ve only been on Tagrisso 80 for a couple months. I’m grateful for it as I’ve just dropped chemo after combo cycle 3 due to bad side effects. My side effects on Tagrisso are very minimal. I brush my teeth with Arm & Hammer toothpaste and rinse with baking soda and water and my mouth does pretty good. Use lots of lotion for dry skin. I’m hoping your posts don’t mean side effects get worse the longer I’m on it, since it’s my only treatment currently.