@smc17 I also did an AI search a few times on this. Not all AI chats are equal. Copilot is worse than chat gpt free and chat gpt free doesn't seem to be as in depth (powerful as Claude). Claude is no longer doing the 30 day free trial. I did go to Chat GPT free. Chat GPT free mentions ANC and the guidelines are anything over 1500 cells/uL is normal but anything less than 500 cells/uL is severe neutropenia. 500-1000 is moderate neutropenia, which do you fall in? The bottom line was that for even those with preexisting low neutrophil counts are not "automatically" excluded from taking Brinsupri. Something that you should talk to your pulmonologist about and get assurance that your WBC's would be closely monitored. In BE the neutrophilic enzymes cause damage to our airways along with increased inflammation (which also damages the tissue) and increased mucus production-not to mention fatigue. Also, to clarify what the pharmacist said, the Brinsupri works in the bone at neutrophil generation, and it blocks the DPP-1 that causes all the problems after the neutrophils do their work. Personally (and I'm not you), my biggest concern is keeping my airways clean and not have the sticky mucus that NTMs, fungus etc get stuck in and able to multiply. So, me testing positive for NTM and taking a risk on these meds is a chance I'm willing to take. But you need to decide what's right for you. I agree with the other post, in learning as much as possible about the drug and what it does and what are the risks. Dr Daly from NJH has a few videos online that cover Brinsupri you can watch, and maybe read the INSMED studies or summaries. Good luck with your decision.