@141emp Hi, I've got UTUC in kidney pelvis with planned kidney/ureter/bladder cuff removal surgery and was placed on Keytruda + Padcev to prep for surgery because ineligible for platinum chemotherapies due to decreased kidney function. Completed two cycles before the skin issues require decreased dose and eventually probably cease but Docs are very encouraged that Signatera went to zero after only one infusion. Telling me that for some patients the worst skin issues have the best long term outcomes. Now am weening off of steroids before surgery. So very grateful for the good care at our teaching hospital here in mid-atlantic.