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Vitamin K: High Doses of MK-4 and MK-7 Show Promising Results
Osteoporosis & Bone Health | Last Active: Jun 6 10:56pm | Replies (107)Comment receiving replies
Regarding supplementation - Doctors are clear about taking calcium and vitamin D which are not FDA approved medications but supplements. When I asked about vitamin K for bone health I was told "no proven benefit". I take that to mean no proper studies, clinical trials etc. like they have to do with prescription drugs for results? It is a bit confusing that calcium and D (sometimes by prescription) are highly recommended but not K? Osteoporosis treatment is vague; I take K anyway.
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@jozer
I take: 180mcg Menaquinone-7 (MK7) - TrueVantage brand and
45,000 mcg (45 mg) of vitamin K2 (menaquinone-4) - Life Extension K2 High Potency brand
I don't think doctors have much interest in vitamins and supplements, other than calcium and Vitamin D. Japan has done studies that found Vit K is beneficial.
Here's a study published by the National Library of Medicine in 2022 that says:
"6. Conclusions
VK supplements showed a small impact on the BMD in postmenopausal or osteoporotic females. A clinically significant effect was seen on clinical and vertebral fractures. The additive effect of VK was found more efficacious. It is positively effective when used in combination or with concomitant therapy. However, the VK2 form displayed a major role in bone formation and was found more effective than its other forms. The meta-analysis of the studies concluded that VK helps to decrease the overall fracture risk, but little evidence showed an insignificant effect on BMD. Long-term use of VK with high dose intake proved to have a beneficial role in increasing BMD and helping to reduce fracture risk in adults. Therefore, more studies are required to strengthen the support of VK as an anti-osteoporotic treatment.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9138595/