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My sister, 47 years old lady from Myanmar with advanced pancreatic adenocarcinoma with multiple liver metastasis, now in Bangkok hospital oncology ward ,on chemotherapy 3rd cycle (Folfirinox regime) , CA19-9 is > 4000 before 1st cycle, then >5000 before C2, then >6000 before C3.
Plan to take PET Scan before C4. Her results show that KRAS G12V mutation . No mutation in BRCA1 & 2. MSI Stable. Tumor Mutational Burden is Low,6 mut/Mb. Is there any chances for her targeted therapy?

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Replies to "My sister, 47 years old lady from Myanmar with advanced pancreatic adenocarcinoma with multiple liver metastasis,..."

Hello @leileitun and welcome to Mayo Clinic Connect. Your sister is fortunate to have you supporting her during this time of treatment!

As you may know, the members of Mayo Connect are not medical professionals, just patients who offer support and encouragement, and also share our experiences with other members. As a result, we cannot help you with your questions about her chances for her targeted therapy.

If she can travel to the Mayo Clinic for a second opinion, that might be helpful. Here is a link with information about obtaining an appointment http://mayocl.in/1mtmR63.

How is your sister feeling? Has she had many side effects from her treatment so far?