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Mounjaro (tirzepatide) in regards to anti-inflammatory-power
Polymyalgia Rheumatica (PMR) | Last Active: May 11 9:01pm | Replies (7)Comment receiving replies
@bettsgca I to had little weird pains )not PMR) that started around 4-5 mg. That is when I too started my .5 mg decrease every 2 weeks, rather than the 1 mg every three that I was doing.
I am not using any maintenance drug but occasionally try Arthritis strength tylenol when I am having one of those days. For example, my pains, post prednisone, seem to come on when I do lots of work. Yesterday I tilled a 2500 square foot garden, did some moving of lumber, and worked on a garage remodel (carpentry) that I started a couple of weeks ago. I had just spent the prior two days doing similar amounts and types of work. I noticed that I am getting more and more sore all over my body when I do this kind of stuff, unless I take a break or slow down. I also notice that if I do not get enough sleep the pain can be worse. the tylenol helps a bit but not really that much in these circumstances.
So, no, I am not back to my old self but it is getting a bit better whenI come off of a few days of this kind of physical output.
Other than thin skin, I did not have many side effects of pred. I did get gastro problems whenI was tapering off, strangely but that subsided when I really made sure to take the pred while eating, not after. No weight gain , but then I started on 15 mg (not 60), and tapered to 12.5 in one month, then to 10 in the next month, etc.
Read my posting of a week ago where I asked others about the post prednisone adrenal insufficiency problem.
Replies to "@bettsgca I to had little weird pains )not PMR) that started around 4-5 mg. That is..."
@petermccarville Thank you Peter. It gives me hope. I have always been active and a skier too. Hoping the prednisone doesn't weaken my bones and I can continue. Read your other posts too. I appreciate that you spend the time telling your journey. It helps. I know we all have different struggles but the gift of this PMR/GCA is to appreciate the good days! Take care.
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@petermccarville and all... Well, my goodness... Geez and Crackers! Jiminy Crickets! Peter C Carville... I'd say you are doing pretty well with your activity level! Wow! I'm thrilled with being able to move my legs and feet. With only arthritis pain increases as I taper Prednisone... If I go below 14mg, I become paralyzed again, hips and legs, quit working, feet won't lift or move. I have serious pain throughout my body.
So, wisely, I am holding indefinitely at 14mg daily. However, I do have increased joint pain, sometimes severe. Extra strength Tylenol is what I use for that. With if needed a kenalog cream I use for Sarcoid flares with rash or pain. The Tylenol takes the edge off, helps but there continues to be an underlying pain, discomfort.
I accept that as just fine in order to stay at 14mg and not go back up to 15 mg where the pain is reduced. I will not risk paralysis or muscle freezing, that still happens if I have an active day... that night I awake about 2-3 a.m. with increased muscle tightness and pain, and take an extra Robaxin muscle relaxer, and a Tylenol. That gets me through to my a.m. pills without a paralysis flare. My own discovery out of fear. Living alone, it's not a good thing to wake up in the morning and not be able to move my muscles, legs/hips or full body. So, I figured I'd hit it head on and this works well.
I have steroid induced diabetes that sent me to the ER last year with coma level glucose. This episode was caused by Oxympic. I took Oxympic to control diabetes for over a year and loved it. No weight loss, but excellent glucose control. Then, I developed every side effect known and was extremely ill with no diagnosis. Immediately off Oxympic and symptoms reduced. Then, glucose went crazy and I was in ER. That began my year from Hell...
I now work with Endocronology to control diabetes with insulin, for life. Started with 5 daily insulin shots plus a long acting shot with Prednisone pills. The doctor put me on Mounjaro, after extreme caution, many, many, questions and fears put to rest... as it is well tested and different than Oxympic. I just increased the dose to 7.5 after several good months at 5mg with no side effects. It actually helps reduces the amount of insulin daily I must have to keep the glucose controlled.
Now, on 7.5mg, I am down to one insulin shot daily, and one long-acting insulin shot with Prednisone pills. That's a dream for me. No weight loss. Pooh. I do need to reduce the Prednisone pounds, but not sure will happen. Probably not level at 14 mg Prednisone. Too bad, as my additional pounds are not healthy. But, I take my wins...
Enjoy your carpentry, and your wonderful activities! You are blessed indeed.
Elizabeth