@shoefly I am very sorry to hear that you have metastatic bone cancer. Please don't look back and blame yourself for not taking anastrozole. We all make decisions that seem right for us at the time. Everything, that I have read, indicates that taking anastrozole, letrozole or exemestane, reduces your risk of recurrence by 40 to 60%. With breast cancer, there are no guarantees. One of the many frustrating factors regarding aromatase inhibitors, is that we have no way of knowing, if they are working. Had you taken one of these drugs for 5 years, you could still have developed bone cancer. One wise and honest nurse practitioner told me that the chance of recurrence is never 0%, no matter what we do. If you were able to enjoy a good quality of life for 5 years, think of that time as a gift. I truly wish you and others, who are faced with a rough road ahead, better health in the future.