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Biochemical Relapse After Lu-177 PSMA — Options for Bone-only mCRPC

Prostate Cancer | Last Active: May 10 8:52pm | Replies (24)
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@jeffmarc, my dad will not respond to Nubeqa (darolutamide) since he is already resistant to Enzalutamide. I was asking about the safety and efficacy of low dose Docetaxel (chemo) at his age.

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Replies to "@jeffmarc, my dad will not respond to Nubeqa (darolutamide) since he is already resistant to Enzalutamide...."
Jeff Marchi | @jeffmarc | May 10 1:52pm

@sumith
I am unsure why you are asking this. You’ve already said he won’t respond to Darolutamide Because he has already Failed Enzalutamide.

In that case going to Darolutamide Is probably not going work at all, and a low-dose of it won’t help.

I know people in their 80s that are using Darolutamide As their only drug and it works great for them. So the safety of the drug is not a problem, the Efficacy of the drug is what Is questioned whether it is a full dose or a half dose.

The two drugs are too similar.

This is a case where you could try BAT. Giving testosterone injections for a few months to see if it will reset the ability for a lutamide drug to work. It works for about 50% of people. The injections of testosterone would definitely make him feel better. The question is, will it raise his PSA too quickly and defeat the purpose.

There are a couple of BAT articles. The second one has a bunch of stuff about treatment of advanced prostate cancer as well.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9313844/
https://online.flippingbook.com/view/150884930/2-3/

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Jeff Marchi | @jeffmarc | May 10 6:36pm

@sumith
Sorry about the wrong answer. I misread Darolutamide for docetaxel.

I have heard of people having low-dose docetaxel A few times. It is easier to handle the side effects from it. In the long run, it ends up with the same results. They give it to you for a longer period of time.

Can’t say for sure how it will affect him, but it would be better than a full dose. Chemo affects everybody differently. Some people have a hard time with it others say it’s not too bad.

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