← Return to Calling all neuropathy people: Tips on footwear and avoiding falls

Discussion
Comment receiving replies
Profile picture for carolynpatten @carolynpatten

@scain Years ago I tried gabapentin but within two days had severe edema and stopped. My doc prescribed amytriptilin, which did nothing, and suggested both pregabalin and Lyrica, but both have similar side effects as gabapentin.
I tried a compound cream, which was mildly helpful at first, then lost effectiveness. I still use a full-specctrum CBD cream and that helps a bit.

Another person on Mayo Connect suggested low-dose naltrexone, and I have an appointment with my doc next month to see about this. It’s been used for years for opiod withdrawal at 20 mg per day and now is being used for chronic pain, including neuropathy, at 1-5 mg per day. Any side effects are supposed to be very mild and not long lasting. Here is a good paper from the Cleveland Clinic that explains how it works.
https://www.clevelandclinicmeded.com/showcase/EKCC138/docs/1430_Hill_Dose.pdf
I have considered both valium and xanax but decided to stay away from both, as I am also very concerned about balance issues with the numbness. I hope this helps — we are all working together to find the answers!

Jump to this post


Replies to "@scain Years ago I tried gabapentin but within two days had severe edema and stopped. My..."

Been on low-dose naltrexone for years. Not much help.