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What if this prevents cancer from becoming resistant?

Prostate Cancer | Last Active: 1 day ago | Replies (45)
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@northoftheborder

Another words, We have not choice?

How define type of cancer? And when We have time to this test?

How some guys live with this on 20-30 years

You're talking about uncontrolled spread, but isn't the PSA level an indicator? As soon as the PSA level rises, we fire the ADT cannon again. Shouldn't that work, since cells depend on hormones?

You've been taking lutamide and ADT for 3-4 years now, and at any moment you could reach a point where they're useless. Aren't you afraid? What's scarier: not having a gun or having a gun but taking it at risk (by refusing ADT)? Are there really no statistics on this?

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Replies to "@northoftheborder Another words, We have not choice? How define type of cancer? And when We have..."
northoftheborder | @northoftheborder | May 9 9:58am

@denis76 Of course I worry about castrate resistance, but the alternative — letting the (castrate-sensitive) prostate cancer run rampant — isn't very appealing.

And we do have some control. For mCSPC, multiple trials have shown that taking an ARSI (like Apalutamide) with ADT significant postpones, and in some cases, may even prevent castrate-resistant cancer cells from waking up and taking over, because it also inhibits their own internal signalling.

Meanwhile, trials continue to test whether its ok to discontinue ADT and go on with just ARSI for people with mCSPC who are exceptional responders.

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