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Profile picture for northoftheborder @northoftheborder

With the addition of ARSIs like the -lutamides, castrate-resistance is postponed indefinitely for some patients; it just depends on the idiosyncrasies of each person's cancer.

And — not a doctor — but I think that the oncology community's thinking is changing from "ADT causes castrate-resistance" to "ADT unmasks castrate-resistance".

If a tiny percentage of your cancer is already castrate-resistant, you won't notice it if you let the castrate-sensitive cancer spread unchecked, just like you won't notice dry rot if your house is on fire. It's only when you put out the fire that the dry rot becomes a problem.

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Replies to "With the addition of ARSIs like the -lutamides, castrate-resistance is postponed indefinitely for some patients; it..."

@northoftheborder

Another words, We have not choice?

How define type of cancer? And when We have time to this test?

How some guys live with this on 20-30 years

You're talking about uncontrolled spread, but isn't the PSA level an indicator? As soon as the PSA level rises, we fire the ADT cannon again. Shouldn't that work, since cells depend on hormones?

You've been taking lutamide and ADT for 3-4 years now, and at any moment you could reach a point where they're useless. Aren't you afraid? What's scarier: not having a gun or having a gun but taking it at risk (by refusing ADT)? Are there really no statistics on this?