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Looking for research re: taking AI drugs vs not taking them

Breast Cancer | Last Active: May 15 10:12pm | Replies (170)

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Profile picture for Rubyslippers @triciaot

@kcalhoun So glad the weight issue cane up! I do a lots of research as well.
Two issues I can’t find enough definitive research on, is fat/weight, and, actual risk of dcis with a papilloma in the peripheral breast (my type) vs central nipple area. It seems papillomas in the outer areas of the breast tend to come in multiples whereas papillomas near the nipple are usually single. Papillomas are usually benign but often aligned with ADH, which can be a precursor for cancer. The oncologist agrees. But the answer seems to be, just keep getting scanned. I keep hoping new research will come out with better outcome info. But this is one reason I chose to do tamoxifen.

The fat/weight issue - it just seems odd that knowing that estrogen is present in fat that that wouldn’t be a super high risk for hormone positive cancer. And as you said, AIs tend to cause weight gain, with tamoxifen not far behind.
“Lower estrogen directly decreases Resting Energy Expenditure (REE) and total energy expenditure.
Estrogen deficiency causes fat to shift from the hips and thighs to the abdominal region (visceral fat), which is metabolically less active and linked to insulin resistance.”
3 1/2 years into low dose tamoxifen I’ve started gaining weight, partly stress eating over family medical/care issues. And having a terrible time losing it. I believe its becuase my metabolic rate has tanked. If fear of scans is scanxiety then I’m feeling bc pfatxiety! I haven’t put on enough weight yet to consider GLP-1 but I’ve got to stop this progression.

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Replies to "@kcalhoun So glad the weight issue cane up! I do a lots of research as well...."

@triciaot Hi! I'm sending my positive waves of healing to you from afar! < 3 Just one finer point to put on this. It isn't just that the estrogen "is present in fat." The adipose (fat) tissue is PRODUCING the estrogen, making it the primary source once the ovaries stop. The enzyme in fat is aromatase, which is the thing you're trying to block with AIs. Significantly overweight women therefore have more circulating estrogen in their body, which then can stimulate the growth of hormone+ breast cancers. I'll repeat my warning that for those with a LOT of extra fat in the midst of a breast cancer battle, AIs may be the way to go to stop that process. I went the GLP-1 way because I couldn't tolerate any of the AIs. And that one more significant thing to know - how much is that AI going to reduce your risk specifically. I ain't living a life of misery in exchange for a 1-2% risk reduction. But for other women, the risk reduction is totally worth it. Not sure what yours is? Go back to those Predicts reports with your unique profile in there. You will see it clearly. Prayers for everybody!!! < 3