@jeffmarc Hi Jeff, Yes they will insert barrier gel & fiducials with the HDR Proton trial and just barrier gel no fiducials with the IMRT option. Like I mentioned, the trial is HDR procedure, barrier & fiducials first (done at same time under GA) then the 5 proton sessions. The other option is separate procedure to insert the barrier gel, then 23 IMRT sessions and brachy boost last. Both would include 4-6 months of ADT. The IMRT option has years of proven success rate. The trial does not have any long term data yet but similar trials have been done in Europe & Canada with success and the same usual standard of care side effects.