Cymbalta, Gabapentin, Aleve, Low Dose Naltrexone, Corticosteroids like Prednisone and Methylprednisolone. I can't take Cymbalta and Aleve anymore due to side effects, but while the lasted they were magic.

Hello @7510cahill and @elained, I would like to welcome you both to Mayo Clinic Connect and thank you for posting. @7510cahill you ask a question that I'm sure a lot of us members may have. I have no medical training or background but believe the answer can be different depending on a lot of factors in our health conditions and body. For me, there is no best medication because I only have numbness with my peripheral neuropathy and no drugs help with numbness according to the Mayo neurologist who diagnosed my idiopathic small fiber PN. I'm tagging our moderator @JustinMcClanahan to see if we should move your post to the following discussion where will have much more visibility and you will meet other member discussing treatments.

Groups > Neuropathy > Living with Neuropathy - Welcome to the group
-- https://connect.mayoclinic.org/discussion/living-with-neuropathy-welcome-to-the-group/

Are you able to share a little more about your diagnosis?

Hi, @7510cahill - you are looking for the best pain medication for pain associated with your neuropathy, correct? You mentioned baclofen, often used for muscle spasms, was recommended. What other medications have you tried thus far?