@gc4217 I took it right from the start. I was already very sick. After my chemo med temozolomide was stopped and my capecitabine was reduced to 2000mg a day, I reduced zofran by taking one day off, then two days off, and so on. I eventually switched to a scopolamine patches, frequently used for motion sickness, for about six months. I then stopped nausea meds altogether. I still get nausea occasionally, but it usually comes with hunger. I eat something, then it subsidies.