← Return to HRT Safety

Discussion
debbie1956 avatar

HRT Safety

Osteoporosis & Bone Health | Last Active: 9 hours ago | Replies (306)

Comment receiving replies
Profile picture for loplady @loplady

@mayblin She had patients who had an ocular stroke as well as blood clots.

Jump to this post


Replies to "@mayblin She had patients who had an ocular stroke as well as blood clots."

@loplady

Yup. Our bodies are very individual.

@loplady was your gynecologist indicating that HRT had caused the ocular stroke and blood clots in these patients and if so were they on a transdermal estrogen patch or oral estrogen? Up to date studies conclude that the patch has a very low risk for blood clots as it bypasses the liver.

@loplady thanks for that info. Coincidentally, I know of two people online who had strokes while on transdermal estrogen. While we can't say for sure HRT is the cause, it’s a sobering reminder of the statistics we have to weigh.

Generally, the transdermal patch is thought to have a much lower clotting risk than the oral version. However, I came across a 2023 review by Dr. Leslie Cho, a cardiologist at the Cleveland Clinic, where she pointed out that the actual quality of studies on this specific safety aspect is still surprisingly 'low', see table 5:
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061559
At the end of the day, your physician and cardiologist are definitely the best ones to help you weigh the bone benefits against the cardiovascular risks since they know your health history best.