@jenelleseaman Thank you for welcoming reply. And for pulling my head out from the doom & gloom of this aggressive cancer. But I was fearful to learn the cancer came back to vaginal cuff. I researched all the details of my particular cancer then when I saw him for the first time after surgery earlier this week on May 4th 2026, I deliberately told him that this high grade carcinogen sarcoma p53 has me very concerned for my survival, and he had his back to me typing things onto my chart on the computer, and he replied, "Yes, it also has me very concerned, too, that is why you are having chemotherapy & radiation," I'm glad he and I shared our thoughts. I'm doing poorly recovering from the first round of chemo. Peripheral neuropathy is bad. And when he suggested he lower the dose of 175 mg of paclitaxel. I knew what he meant without saying it. He'd want to switch me over to docetaxel. I told him I'm tough and hope I develop a tolerance to paclitaxel. It's 9 days since 1st chemo and my intestines feel weird/slow motility & feels bloated, but like Im wearing a really tight girdle 5x too small pushing painful pressure over my intestines as they shift into the open space of the removed uterus. I believe I am struggling with some level of side effects from Taxol (paclitaxel), and oncologists may prescribe docetaxel (brand name Taxotere) as a viable alternative. Both are taxanes, but they have different chemical structures and toxicity profiles. Oncologists typically switch from paclitaxel to docetaxel for the following reasons: Hypersensitivity Reactions: Taxol is formulated with a solvent called Cremophor EL, which frequently causes acute allergic reactions. Docetaxel uses a different solvent (polysorbate 80) and may be better tolerated by patients who experience severe hypersensitivity to Taxol. Peripheral Neuropathy: While both drugs can cause nerve damage, some studies and clinical observations suggest docetaxel may have a lower incidence or less severe presentation of peripheral neuropathy (numbness and tingling) compared to paclitaxel. Treatment Schedule: Docetaxel is often administered every three weeks, whereas Taxol is frequently given weekly. A switch may be made to manage the cumulative dose and patient quality of life. Other Potential Alternatives If docetaxel is also not tolerated or if the primary issue is the solvent, doctors might consider: Nab-paclitaxel (Abraxane): An albumin-bound form of paclitaxel that contains no solvents, significantly reducing the risk of allergic reactions and often allowing for higher doses without the need for premedication steroids. Ixabepilone (Ixempra): A non-taxane chemotherapy (epothilone) that works similarly to taxanes but may be effective when cancers become resistant to them. You said the cancer came back in quite a few places. What did you do when this news hit you? What treatments? Where are you now in the journey? You are a window perhaps into my future. Praise God that I found you. Thank you for your prayers. Linda