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ADT started before SRT or concurrently?

Prostate Cancer | Last Active: May 7 7:43pm | Replies (17)

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@brianjarvis
Thanks Brian for this info. I tried to find studies done for salvage RT and could not find any. The closest that I found was this on UCLA site :

"Researchers observed a significant interaction between ADT sequencing and RT field size for all study endpoints except overall survival. For patients receiving prostate-only RT, ADT occurring during and after radiation was associated with improved metastasis-free survival compared with neoadjuvant/concurrent ADT.

However, with patients receiving whole-pelvis RT, no significant difference was observed with ADT sequencing, except greater distant metastasis occurrence among those who had concurrent/adjuvant ADT. "

This statement is also referring to initial whole prostate RT (primary RT) , but the last sentence refers to the "whole pelvis" RT which is actually more similar to salvage RT, I guess ?

I you happen to have any papers that refer specifically to salvage RT and initiation of ADT timing, please post them here (when you find time) - thanks so much in advance 🙏.

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Replies to "@brianjarvis Thanks Brian for this info. I tried to find studies done for salvage RT and..."

@surftohealth88 Dr. Kwon (of Mayo Clinic) has a 2019 PCRI presentation addressing Mayo’s protocol for salvage treatment of recurrence (following surgery and radiation). At various places in his presentation he covers what you’re asking about.

See Dr. Kwon’s presentation about recurrence at: https://youtu.be/Q2joD360_pI)