Absolutely feel your pain. I have suffered with nocturnal leg cramps for at least 40 years and have tried every suggestion given. Mine are mostly in my toes, shins and calves. Occasionally they will affect my thighs which are by far the most excruciating and unbearable. For the last 6-7 months I have been using Theraworx for Muscle Cramps roll-on at bedtime and then use a heating pad for 10-15 minutes while laying in bed. If you try this be sure to follow the directions using 2 applications. Theraworx had other modes like spray foam, etc. The roll-on works best for me. I also take Cramp Defense supplements (4 pills after dinner). Start slowly with these. I also try to walk 2 miles every day. I was recently diagnosed with pn - pins and needles in the bottom of my feet and lower legs most noticeable in the evening and early a.m. and recently started taking 20mg. of duloxetine at dinner. This has cut that "sensation" by about 80%. (hardly noticeable during the daytime).