@wews thanks for the info about your surgery, it makes sense! So, in my case, the first oncologist at my medical center wouldn't even consider Tamoxifen due to the possible risks. But I ended up at a really great cancer center, Fred Hutchinson in Seattle & my new oncologist (with far better credentials) insisted 100% on Tamoxifen due to my history of low bone density. And his conviction resonated with me. He initially suggested 20 mg (usual dose) but I wanted to try a half-dose (10 mg) which would mitigate side effects. And he agreed based on the fact that there are large, ongoing clinical trials evaluating the effectiveness of 10 mg (& probably also 5 mg, I'm guessing). He said, "why would they be spending the time & money on trials if they didn't believe there was a basis for lower doses?". So, I started 10 mgs of Tam on Jan. 1st. The first week I had a mild headache off & on. But now, I just pop the little pill each night along with my statin & I don't even think about it! No side effects. The risk for uterine cancer is very low, but not zero. They suggest having pelvic exams (no, thanks) & otherwise, obviously, to watch for any bleeding. Some people choose regular uterine ultrasounds but that's not standard. Here's a fun fact: I had been experiencing frequent bouts of indigestion & acid reflux for a couple of years, especially if I was stressed. Since starting Tam, I haven't had any stomach issues at all! Which is maybe a coincidence, but either way, I'll take it! And I like knowing that it's helping to protect my bones. So, it's been a perfect fit for me (SO FAR! Especially if it prevents any recurrance!). Hope this is helpful! Sending best wishes!