@californiazebra, I had the GI effects. The effects are said to (and did) last into the next injection. Many weeks after the second injection, I that I understood that couldn't maintain sufficient weight on Repatha. I hope you have a healthier response. Leqvio has a different mechanism of action that Repatha or Praluent, so even though I'm planning Leqvio, I'm avoiding the cardiologist for a (dangerous) while.