I was on 60 mg of Duloxetine for 9 months for neuropathy in my feet/lower legs. Couldn't tell that it helped much but one thing it did do which was uncontrollable diarrhea. Caused me to get microscopic colitis. Dr. weaned me off it going from 60 to 40 and then 20 mg for two weeks. Been totally off it now for several weeks. Withdrawal symptoms have been nasty. Have terrible insomnia, not falling asleep until 1-2 am. Also have restless legs which drive me nuts while trying to fall asleep. Avoid this drug like the plague.