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P1NP number on Tymlos

Osteoporosis & Bone Health | Last Active: 2 days ago | Replies (64)

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@mayblin
I started HRT and Tymlos at the same time. I may have started HRT just a couple weeks before Tymlos but definitely not before my first bone markers were done in May 2025

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Replies to "@mayblin I started HRT and Tymlos at the same time. I may have started HRT just..."

@lurawilson, thanks for sharing this info. I’ve always wondered about using HRT along with a PTH analog. There was a clinical study for teriparatide combined with HRT that showed a positive outcome, though 40mcg teriparatide - doubled the standard dose 20mcg found in Forteo - was used in the study.

Occasionally we hear anecdotal accounts of using the combo with good bmd gains, but your bone markers are offering a rare look into this less-studied combination. To me, even though the two agents involved here may have a 'tug of war' with opposing effects, your 3-mo readings were clearly favorable, with the P1NP percent-increase outpacing CTX. That initial lead might just be enough to result in a positive bmd outcome. Fingers crossed!

@lurawilson I am 77 years of age and my doctors are negative on starting HRT after more than 20 years in menopause. May I ask about age when you began HRT?