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tongxiaozhi avatar

Treatment of lung adenocarcinoma

Lung Cancer | Last Active: 12 hours ago | Replies (26)

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Profile picture for Matthew K @flusshund

@tongxiaozhi, I don't know that the word "usually" is appropriate, maybe "sometimes". My friend Frank has the same Exon 21 mutation and has been taking Tagrisso for 10 years with no resistance. I know an MD Anderson Dr who has a patient that has been taking Tagrisso for 12 years without resistance.

Tagrisso is a targeted therapy that does not hunt down and kill cancer cells. Rather, it keeps existing cancer cells from infecting healthy cells and spreading. So if surgery and/or radiation can eliminate the visible nodules, then the idea is that Tagrisso can keep any isolated cells from multiplying and becoming a problem. I wish you and your mother all the best.

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Replies to "@tongxiaozhi, I don't know that the word "usually" is appropriate, maybe "sometimes". My friend Frank has..."

@flusshund Thank you so much for sharing this—it’s really encouraging to hear about your friend and the long-term responses some patients have had with Tagrisso. That gives us a lot of hope.

I also appreciate your explanation of how Tagrisso works. It’s helpful to think about it as controlling the cancer and preventing spread, especially in combination with treatments like surgery or radiation when appropriate.

If you don’t mind me asking, what stage was your cancer when you started taking Tagrisso? My mom is currently stage IV, and her doctors in China have mentioned that resistance can sometimes develop after one or two years. Hearing your experience makes me feel more reassured.

Also, at the beginning of your treatment, were you taking Tagrisso alone, or was it combined with chemotherapy?

Thank you again for your kindness and for sharing your experience. Wishing you continued good health and all the best. 🙏🏻