Hi @annietran0419. I am so, so glad you found Mayo Clinic Connect. You have landed where members share information and encouragement. It has to be difficult to walk with your son through this struggle trying to heal his stubborn duodenum ulcer.

Mayo Clinic has information you may find helpful as you wait for others to comment. I want to particularly draw attention to a section, ‘Ulcers that don't heal’.
- Peptic ulcers that don't heal with treatment are called refractory ulcers. Reasons for an ulcer not healing include:
* Not taking medicines as prescribed.
* Having a type of H. pylori that resists antibiotics.
* Often using pain relievers, such as NSAIDs, that increase the risk of ulcers.
* Less often, refractory ulcers may be a result of: A lot of stomach acid, such as happens in Zollinger-Ellison syndrome, an infection other than H. pylori, or stomach cancer.
- Other conditions that may cause ulcerlike sores in the stomach and small intestine, such as Crohn disease.

I will drop a link to the entire overview if you have not seen it:
- Mayo Clinic Peptic Ulcer Overview
https://www.mayoclinic.org/diseases-conditions/peptic-ulcer/symptoms-causes/syc-20354223
You may also find it helpful to search for key words from the Connect home page to learn more.

I am a patient of Mayo Clinic who has struggled through what they have called a marathon of helping my quality of daily living. I cannot say enough about their integrative approach to problem solve and find solutions. I don’t know where you live and how feasible it would be to visit but I do notice their overview lists providers at their MN location specializing in treating peptic ulcers. For me, I reached a point that it wasn’t worth not making the 7-hour car ride. It is straightforward to pursue an appointment if you are interested.

Connect with Mayo Clinic for an appointment here: http://mayocl.in/1mtmR63

How does your son physically feel overall, how about emotionally? How are you?