I was taking this for years due to chronic back pain due to severe lumbar and cervical stenosis, along with bilateral neuropathy and OA. Unfortunately, it didn't work well enough. As my doctor stated, Chronic pain trumps any possible medication. Switched to Dilaudid for years but needed to wean off due to potential addiction. Since then, I have tried micro dosing Suboxone, Lyrica gabapentin, and various other meds. Not much helped, since my pain increased post a failed back surgery 5 yrs ago. Tramadol did help, however, but again, poses possible addiction. Currently trying Low dose naltreone, along with celebrex , Tylenol and zanadol (muscle relaxer). Its a daily struggle with OA, pinched nerves and stenosis. My daily pain level hovers around a constant 7 with all these meds. The frustration is overwhelming which goes hand in hand will major depression. My mantra remains "it can always be worse" but pushing through is exhausting, especially when you have a healthy spouse that wants to be active and doesn't grasp the intense pain